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exosome mediated differentiation of megakaryocytes: a study on tlr mediated effects
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نویسنده
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kovuru narasaiah ,raghuwanshi sanjeev ,gutti ravi kumar
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منبع
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journal of thrombosis and thrombolysis - 2019 - دوره : 48 - شماره : 1 - صفحه:171 -173
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چکیده
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Megakaryocytes are large polyploid bone marrow cells whose function is to produce circulatory platelets. megakaryocytes are also known to release extracellular vesicles (evs) of varying sizes. toll like receptors (tlrs), present on the sentinel cells are essential components of the innate immune response, these receptors are also expressed by platelets and megakaryocytes. our data provide the evidence that tlr-2 induced mkevs are able to recapitulate tlr-2 signalling in megakaryocytic cell line (dami cells) and that likely induces megakaryocytic maturation by increasing the production of cytokines involved in mk maturation. tlr-2 induced mkevs be involved in replenishment of the immune effector platelets in circulation and its progenitor megakaryocyte in bone marrow for the physiological need of the platelets by inducing the maturation of megakaryocyte.
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کلیدواژه
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megakaryocyte ,extracellular vesicles ,exosomes ,tlr-2
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آدرس
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university of hyderabad, school of life sciences, department of biochemistry, india, university of hyderabad, school of life sciences, department of biochemistry, india, university of hyderabad, school of life sciences, department of biochemistry, india
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Authors
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