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carbamazepine interaction with direct oral anticoagulants: help from the laboratory for the personalized management of oral anticoagulant therapy
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نویسنده
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gennaro leonardo di ,lancellotti stefano ,cristofaro raimondo de ,candia erica de
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منبع
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journal of thrombosis and thrombolysis - 2019 - دوره : 48 - شماره : 3 - صفحه:528 -531
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چکیده
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Current guidelines recommend caution in prescribing concomitant use of direct-acting oral anticoagulants (doacs) and antiepileptic drugs due to drug–drug interactions leading to potential risk of doacs subtherapeutic concentration and treatment failure. herein we report a significant interaction between carbamazepine (czp) and apixaban, causing subtherapeutic concentration of the drug in a patient with atrial fibrillation who had a transient ischemic attack (tia) episode. another anti-xa doac, edoxaban, administered to the patient after tia occurrence did not show significant interaction with czp. in addition to confirm that cautions should be used when antiepileptic and doacs are concomitantly prescribed, the present case also demonstrates that, in the management of certain subsets of patients who need anticoagulant treatment, measurement of doac plasma concentration can help guide a personalized management and avoid adverse clinical outcomes.
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کلیدواژه
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direct oral anticoagulant ,doac interaction ,carbamazepin ,anti-xa activity ,personalized oral anticoagulant therapy
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آدرس
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fondazione policlinico universitario “agostino gemelli”, unità operativa malattie emorragiche e trombotiche, italy, fondazione policlinico universitario “agostino gemelli”, unità operativa malattie emorragiche e trombotiche, italy, fondazione policlinico universitario “agostino gemelli”, unità operativa malattie emorragiche e trombotiche, italy. università cattolica del sacro cuore, italy, fondazione policlinico universitario “agostino gemelli”, unità operativa malattie emorragiche e trombotiche, italy. università cattolica del sacro cuore, fondazione policlinico universitario “agostino gemelli”, unità operativa malattie emorragiche e trombotiche, italy
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Authors
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