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   change in matrix metalloproteinase 2, 3, and 9 levels at the time of and after acute atherothrombotic myocardial infarction  
   
نویسنده owolabi ugochukwu shola ,amraotkar alok ravindra ,coulter amanda r. ,singam narayana sarma v. ,aladili bahjat n. ,singh ayesha ,trainor patrick james ,mitra riten ,defilippis andrew paul
منبع journal of thrombosis and thrombolysis - 2020 - دوره : 49 - شماره : 2 - صفحه:235 -244
چکیده    Elevated measures of matrix metalloproteinases (mmps) are associated with acute myocardial infarction (mi), but it is not known how long these changes persist post-mi or if these measures differ between atherothrombotic versus non-atherothrombotic mi. mmps-2, 3, and 9 were measured in 80 subjects with acute mi (atherothrombotic and non-atherothrombotic mi) or stable coronary artery disease (cad). measurements were made at, the time of acute mi, and > 3-month following acute mi (quiescent phase). outcome measures were compared between groups and between time of acute mi and quiescent post-mi follow-up using wilcoxon’s and repeated measures analysis of variance. forty-nine subjects met the criteria for acute mi with clearly defined atherothrombotic (n = 22) and non-atherothrombotic (n = 12) subsets. fifteen subjects met criteria for stable cad. mmp-3 was higher in acute mi versus stable cad subjects at the time of acute mi: (453 vs. 217 pg/ml, p = 0.010) but not at quiescent phase follow-up (p > 0.05). mmp-9 was higher in acute mi versus stable cad subjects at the time of acute mi: (412 vs. 168 pg/ml, p = 0.002) but not at the quiescent phase follow-up (p > 0.05). mmp-9 was higher at the time of acute mi versus quiescent phase follow-up in acute mi (412 vs. 213 pg/ml, p = 0.001) and atherothrombotic mi specifically (458 vs. 212 pg/ml, p = 0.001). no difference in mmp-2, 3, or 9 was observed between atherothrombotic versus non-atherothrombotic mi subgroups. mmps-3 and 9 are significantly elevated in acute mi verses stable cad subjects at time of acute mi but not different at quiescent phase follow-up. mmp-9 is elevated at the time of acute mi and specifically in acute atherothrombotic mi at time of mi versus quiescent phase follow-up.
کلیدواژه atherothrombosis ,acute myocardial infarction ,metalloproteinases ,extracellular matrix
آدرس university of louisville, diabetes & obesity center, department of bioinformatics and biostatistics, usa, university of louisville, diabetes & obesity center, division of cardiovascular medicine, usa, university of louisville, diabetes & obesity center, division of cardiovascular medicine, usa, university of louisville, division of cardiovascular medicine, usa, university of louisville, division of cardiovascular medicine, usa, university of louisville, school of medicine, usa, university of louisville, division of cardiovascular medicine, usa. new mexico state university, easib department, usa, university of louisville, department of bioinformatics and biostatistics, usa, university of louisville, division of cardiovascular medicine, usa. johns hopkins university, ciccarone center for the prevention of heart disease, usa
 
     
   
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