>
Fa   |   Ar   |   En
   covid-19: are we dealing with a multisystem vasculopathy in disguise of a viral infection?  
   
نویسنده mondal ritwick ,lahiri durjoy ,deb shramana ,bandyopadhyay deebya ,shome gourav ,sarkar sukanya ,paria sudeb r. ,thakurta tirthankar guha ,singla pratibha ,biswas subhash c.
منبع journal of thrombosis and thrombolysis - 2020 - دوره : 50 - شماره : 3 - صفحه:567 -579
چکیده    After the emergence of severe acute respiratory syndrome coronavirus (sars-cov) and middle east respiratory syndrome coronavirus (mers-cov) in the last two decades, the world is facing its new challenge in severe acute respiratory syndrome coronavirus 2 (sars-cov-2) pandemic with unprecedented global response. with the expanding domain of presentations in covid-19 patients, the full range of manifestations is yet to unfold. the classical clinical symptoms for sars-cov-2 affected patients are dry cough, high fever, dyspnoea, lethal pneumonia whereas many patients have also been found to be associated with a few additional signs and clinical manifestations of isolated vasculopathy. albeit a deep and profound knowledge has been gained on the clinical features and management of covid-19, less clear association has been provided on sars-cov-2 mediated direct or indirect vasculopathy and its possible correlation with disease prognosis. the accumulative evidences suggest that novel coronavirus, apart from its primary respiratory confinement, also invade vascular endothelial cells of several systems including cerebral, cardio-pulmonary as well as renal microvasculature, modulating multiple visceral perfusion indices. here we analyse the phylogenetic perspective of sars-cov-2 along with other strains of β-coronaviridae from a standpoint of vasculopathic derangements. based on the existing case reports, literature and open data bases, we also analyse the differential pattern of vasculopathy related changes in covid-19 positive patients. besides, we debate the need of modulation in clinical approach from a hemodynamical point of view, as a measure towards reducing disease transmission, morbidity and mortality in sars-cov-2 affected patients.
کلیدواژه vasculopathy ,sars-cov-2 ,ace2 ,endothelium ,hemodynamics ,thrombosis ,hypercytokinemia
آدرس sskm hospital, institute of post graduate medical education and research, india, sskm hospital, institute of post graduate medical education and research, india, university of calcutta, s.n. pradhan centre for neuroscience, india, sskm hospital, institute of post graduate medical education and research, india, university of calcutta, department of microbiology, india, csir-indian institute of chemical biology, india, sskm hospital, institute of post graduate medical education and research, india, kpc medical college and hospital, india, gian sagar medical college and hospital, india, csir-indian institute of chemical biology, india
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved