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clinical significance of healed plaque detected by optical coherence tomography: a 2-year follow-up study
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نویسنده
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kurihara osamu ,russo michele ,kim hyung oh ,araki makoto ,shinohara hiroki ,lee hang ,takano masamichi ,mizuno kyoichi ,jang ik-kyung
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منبع
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journal of thrombosis and thrombolysis - 2020 - دوره : 50 - شماره : 4 - صفحه:895 -902
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چکیده
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Recent studies have shown that healed plaque at the culprit lesion detected by optical coherence tomography (oct) is a sign of pan-vascular vulnerability and advanced atherosclerosis. however, the clinical significance of healed plaque is unknown. a total of 265 patients who had oct imaging of a culprit vessel and 2-year clinical follow-up data were included. patients were stratified based on the presence or absence of a layered plaque phenotype, defined as layers of different optical density by oct at either culprit or non-culprit lesions. the association between layered plaque and major adverse cardiac events (mace), defined as cardiac death, acute coronary syndromes (acs), or revascularization, was studied. among 265 patients, 96 (36.2%) had the layered plaque phenotype. layered plaque was more frequently observed in stable angina pectoris patients than in acs patients (57.8%vs. 25.1%, p < 0.001). the average clinical follow-up period was 672 ± 172 days. cumulative mace was significantly higher in patients with layered plaque (p = 0.041), which was primarily driven by the high revascularization rate at 2 years (p = 0.002). multivariate regression analysis showed that presence of layered plaque and low-density lipoprotein cholesterol levels were independently associated with an increased risk of revascularization (p = 0.026, p = 0.008, respectively). patients with healed plaque in the culprit vessel had a higher incidence of revascularization, as compared to those without healed plaque, at 2 years.
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کلیدواژه
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optical coherence tomography ,healed plaque ,layered plaque ,revascularization
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آدرس
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harvard medical school, massachusetts general hospital, cardiology division, usa, harvard medical school, massachusetts general hospital, cardiology division, usa, harvard medical school, massachusetts general hospital, cardiology division, usa, harvard medical school, massachusetts general hospital, cardiology division, usa, harvard medical school, massachusetts general hospital, cardiology division, usa, harvard medical school, biostatistics center, massachusetts general hospital, usa, nippon medical school chiba hokusoh hospital, cardiovascular center, japan, mitsukoshi health and welfare foundation, japan, harvard medical school, massachusetts general hospital, cardiology division, usa. kyung hee university hospital, department of cardiology, korea
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Authors
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