Protective effect of caffeic acid phenethyl ester against lead acetate-induced hepatotoxicity in mice [Farede kurşun asetatla oluşturulan hepatotoksisiteye karşi{dotless} kafeik asit fenetil esterin koruyucu etkisi]

The toxicity of lead in the liver seems to relate to the generation of reactive oxygen species (ros). caffeic acid phenethyl ester (cape),a flavonoid like compound,is one of the major components of honeybee propolis which has been demonstrated to have antioxidant,free radical scavenger. this study was designed to investigate the protective effects of the cape against lead acetateinduced hepatotoxicities in mice. a total of 25 mice were equally divided into 5 groups which were: 1st control,2nd injected with intraperitoneally (ip) %1 ethanol. 3rd injected with ip cape,4th injected with ip lead-acetate,5th injected with ip cape + lead acetate. experimental animals were decapitated at the end of the study. following systemic necropsies of the animals,tissue paraffin blocks were prepared and cut into 5 μm thick sections for hematoxylen-eosin staining. the samples were later monitored under a light microscope for histopathological changes. in conclusion,livers which were treated with 1% ethanol and cape were similar to control group. in the group which was treated with lead some degenerations and necrosis were observed. in the group which was treated with cape and lead,levels of necrosis and degenerations was observed in less degree.