The effects of ketoprofen and meloxicam on bone healing in rat model: A comparative dual energy x-ray absorptiometry study [ketoprofen ve meloksikam'i{dotless}n kemik i̇yileşmesi üzerine etkilerinin rat modelinde dexa ölçümleri ile deǧerlendirilmesi]

Pain control is a common clinical approach in trauma and postoperative care especially complicated orthopedic surgeries to ease the deleterious effects of pain. various kinds of pain killers have been used,and nowadays nonsteroidal anti-inflammatory drugs (nsaids) are among the most commonly used drugs for pain control purposes. prostaglandin-endoperoxide synthetase,also commonly called cyclooxygenase (cox),is one of the key enzymes in prostaglandin bio-synthesis. the cox enzymes have subgroups of enzymes,each of which suppresses different inflammatory mediators. these enzymes are involved in different functions,some of which are essential for continuity of physiological processes. thus,nsaids are expected not to cause any change of functions of some enzymes while suppressing others. among the cox enzymes,cox-1 is associated with gastrointestinal system functions and gastrointestinal mucosa while cox-2 is associated with inflammation and pain. like most drugs,nsaids have known and possible side effects. in various studies related to nsaids,inhibitory effects of conventional nsaids with non-selective effects and specific cox-2 inhibitors on bone healing have been reported. in this study,the effects of ketoprofen and meloxicam on bone fracture healing induced in 24 adult male wistar rats was studied by dual energy x-ray absorptiometry (dexa). the results indicates that meloxicam inhibits the fracture healing to some degree.