Direct role of α2-adrenoreceptors in antiulcer effect mechanism of tianeptine in rats [Si{dotless}çanlarda Tianeptinin Antiülser Etki Mekanizmasi{dotless}nda α2-Adrenoreseptörlerin Direkt Etkisi]

Tianeptine is an anti-depressant drug that also has an anti-ulcer activity. in this study,it was investigated whether or not α2-adrenoreceptors have a role in the anti-ulcer effect mechanism of tianeptine. furthermore,we investigated both intact and adrenalectomized rats to determine whether or not the anti-ulcer activity of tianeptine is related to adrenal gland hormones involved in this mechanism. in all rats,25 mg/kg indomethacin produced gastric ulceration. tianeptine was administered to the indomethacin-induced ulcers in the rats at different doses. yohimbine,selective α2-receptor blocker,was given (10 mg/kg) to some rats (adrenalectomized 6 groups and intact 4 groups),for blockage of the α2-receptor. tianeptine showed antiulcer effects of 59.6-81.6% in all animals. the results of this study show that tianeptine caused a significant anti-ulcer activity in both adrenalectomized and intact rats. tianeptine does not have an anti-ulcer effect in rats which have been given yohimbine. thus,the adrenal gland hormones do not have a direct effect on the anti-ulcer activity of tianeptine. this drug may be directly related to the α2-adrenoreceptors. moreover,the anti-ulcer effect shows an increase in parallel with increasing dose. this property of tianeptine could make it suitable for use in the treatment of both depression and peptic ulcer patients.