An immunohistochemical study of the insulin-,glucagon-,orexin A- and ghrelin- immunoreactive cells in the endocrine pancreas of guinea pig [Kobay endokrin pankreasi{dotless}nda insülin-,glukagon-,orexin A- ve ghrelin- immunoreaktif Hücrelerin immunohistokimyasal Çali{dotless}şmasi{dotless}]

The present study was conducted to clarify the regional distribution and relative frequency of endocrine cells secreting insulin,glucagon,orexin a (oxa) and ghrelin in the pancreatic islets of guinea pig,by specific immunohistochemical methods. in the pancreatic islets,most of insulin-ir cells were detected in the central region,partially in mantle region. glucagon-ir cells were located in the periphery of the pancreatic islets. in addition,they had lower frequency in the central region. oxa and ghrelin- ir cells were identifed in central and peripheral regions of the pancreatic islets. clearly,oxa-ir cells exhibited a characteristic distribution pattern resemble to those for the glucagon- ir cells. however,ghrelin immunoreactivity exhibited a characteristic distribution pattern different from that of insulin-immunoreactive cells. in conclusion,some species-dependent unique distributions characteristics of endocrine cells in the pancreatic islets were observed in the guinea pig.