Influence of the route of administration on therapeutic efficacy of ivermectin in saanen and damascus goats naturally infected with trichostrongylidae spp [Trichostrongylidae spp. ile doǧal enfekte saanen ve damascus (Halep) keçilerinde i̇vermektinin terapötik etkinliǧi üzerine uygulama yolunun etkisi]

The aims of this study were to compare the therapeutic efficacy of ivermectin after subcutaneous,per os and pour-on administration in saanen goats naturally infected with trichostrongylidea spp. and to evaluate the efficacy of ivermectin pour-on in damascus goats with similar gastrointestinal nematodes. after body weighing and faecal sample collection on day 0 (pre-treatment day),45 saanen goats were weighed,faecal sampled and allocated on the basis of day -3 faecal egg counts (fec) to four treatment groups (n=9 in each group). saanen goats were then treated with a single dose of ivermectin at a dose rate of 0.2 mg/kg by subcutaneous injection or oral administration and 0.5 mg/kg or 1 mg/kg by topical application. nine saanen goats were kept as non-medicated control. fifteen damascus goats were divided two groups. the first group (n=9) received ivermectin pour-on as a single dose of 0.5 mg/kg and the second group (n=6) served as a non-medicated control. the efficacy was measured on the basis of the reduction of the egg output and the evaluation of the results from larval differentiation on 14 days post-treatment. in saneen goats,ivermectin provided equally excellent (100%) therapeutic efficacy after subcutaneous or oral administration whereas ivermectin pour-on treatment at a dose of 0.5 mg/kg and 1.0 mg/kg reduced pretreatment fec by 96.5% and 99.9%,respectively. no statistically significant difference was found between 1.0 mg/kg of ivermectin by topical application and the ivermectin subcutaneous and oral treated groups for post treatment fec whereas the efficacy of ivermectin pour-on at 0.5 mg/kg was significantly lower than that for each of the other 3 treatment groups. in damascus goat,the therapeutic efficacy of 0.5 mg/kg ivermectin pour-on was recorded as only 30.7%.