Degranulation effects of sunset yellow-FCF on dermal and intestinal mast cells of chicken embryo [Sunset yellow FCF' nin tavuk embriyosu deri ve barsak mast hücrelerinin degranülasyonu üzerindeki etkileri]

In this study,the degranulation effect of sunset yellow (e110) which is used as artificial coloring agent in ready food was histologically examined on dermal and mucosal mast cells of chicken embryo. sunset yellow (2.5 mg/kg) was injected into vitellus of eggs on the 15th day of incubation. degranulation of dermal and mucosal mast cells were evaluated 6,12,24 h after injection. the most of partial degranulated in dermal mast cells (skin) was observed after 12 h from injection of sunset yellow,and after 6 h in mucosal mast cells (intestine). high level degranulation in skin was showed after 24 h from injection,and after 12 h in intestine. also,it was seen that high level degranulation in the mucosal mast cells of intestine were continued after 24 h from injection. in both types of tissues,it was found that partially degranulated mast cells formed loose and coarse granules while mast cells showing high level of degranulation have brighter cytoplasm since they contain less granuless.