The effects of cadmium,copper and lead on in Vitro bovine uterine contractility [Kadmiyum,baki{dotless}r ve kurşunun i̇n vitro i̇nek uterus kasi{dotless}lmalari{dotless} üzerine etkileri]

The aim of this study was to investigate in vitro effects of cadmium,copper and lead on isolated bovine uterus contractions at follicular and luteal stage. in this study myometrial strips obtained from healthy holstein cows slaughtered in kirikkale slaughterhouse were used. the strips were mounted to isolated organ bath under a basal tension of 2 g. the effects of 105 m cadmium,10-4 m copper and 104 m lead on the spontaneous,2.5 miu/ml oxytocin and 106 m pgf2 alpha induced contractions were examined. at follicular stage,all contractility parameters (maximum and mean amplitudes and frequency) of uterine induced by oxytocin and prostaglandin f2 alpha (pgf2 alpha),and at the luteal stage all contractility parameters of spontaneous,oxytocin and pgf2 alpha induced contractions were decreased significantly by cadmium. at follicular stage the maximum and mean amplitude of spontaneous contractions,all contractility parameters induced by oxytocin,the frequency and maximum amplitude caused by pgf2 alpha and,at the luteal stage the maximum amplitude of spontaneous contractions,the frequency and maximum amplitude of uterine contractions induced by oxytocin,and maximum-mean amplitude of contractions induced by pgf2 alpha were decreased by copper. while lead decreased the frequency of uterine contractions induced by pgf2 alpha and oxytocin at follicular and luteal stage,at luteal stage it increased the mean amplitude of spontaneous contractions. it was suggested that cadmium,copper and lead changed the contractility of bovine uterine; therefore this may be effect the fertility in cattles.