Effects of acrylamide treatment on oxidant and antioxidant levels in rats [Ratlarda akrilamid kullani{dotless}mi{dotless}ni{dotless}n antioksidan ve oksidan deǧerleri üzerine etkisi]

The aim of this study was to investigate serum total antioxidant status (tas),total oxidant status (tos) and ischemia-modified albumin (ima) levels in long term acrylamide (acr) given rats,compared to control rats. in total,25 male and 25 female wistar rats were involved in this experiment. animals in each sex were segregated into three groups. two of them were treatment groups and one of them was control group. each treatment group consisted of ten animals and each control group consisted of five animals. acr was administered to the treatment groups at 2 and 5 mg/kg/day via drinking water for 90 days. in the end of the experiment,serum samples were analyzed for ima,tas,tos and albumin levels with the spectrophotometric method. serum ima and adjusted ima levels were significantly higher at concentrations of 2 mg/kg and 5 mg/kg in the male rats when compared with those of the control male rats. serum tas levels significantly decreased at concentrations of 5 mg/kg in the male rats when compared with those of the control rats. we also observed a significant increase in the levels of serum tos at concentrations of 5 mg/kg in the male rats. there were no significant differences between serum ima,tas,tos and albumin levels at concentrations of 2 mg/kg and 5 mg/kg in the female rats. our findings show that long term treatment with 2 mg/kg and 5 mg/kg doses of acr led to a significant depletion of serum tas levels and overproduction of serum tos and ima levels,consequently,to an increase in oxidative stress.