Investigation of the effects of alpha lipoic acid application on total antioxidant and oxidant status,paraoxonase,and total sialic acid levels in laminectomized rabbits [Laminektomi yapi{dotless}lan tavşanlarda alfa-lipoik asit uygulamalari{dotless}ni{dotless}n total antioksidan kapasite,total oksidan kapasite,paraoksonaz ve total sialik asit düzeyleri üzerine etkilerinin araşti{dotless}ri{dotless}lmasi{dotless}]

The objective of this study is to investigate the effect of intramuscular administration of alpha-lipoic acid (ala) on total antioxidant (tas),total oxidant (tos),paraoxonase (pon) and total sialic acid (tsa) levels in laminectomized rabbits. in the study,twenty four white new zeeland rabbits weighing 3-4 kg were used. the investigation was carried out with three experiment and one control group consisting of six animals of each. no intervention has been done to the control group. animals in the group i received 50 mg/kg/day im ala (thioctacid 600 t,m,eda,hamburg) without undergoing laminectomy. group ii underwent laminectomy; group iii underwent laminectomy and treated with im ala. the experiment lasted 45 days and blood samples were taken on 0,15th,30th,and 45th days from the animals. tas,tos,pon and tsa levels were measured in the serum. we conclude that ala treatment would be beneficial in laminectomized rabbits in order to suppress inflammatory process and to expedite recovery.