Effects of cysteamine,putrescine and cysteamine-putrescine combination on 3-Methylcholanthrene-induced fibrosarcoma in mice [Farelerde 3-Metilkolantrenle i̇ndüklenen fibrosarkoma üzerine sisteamin,putresin ve sisteamin-putresin kombinasyonunun etkileri]

In this study the effects of cysteamine,putrescine and the combination of cysteamine and putrescine were investigated in mice with 3-methylcholanthrene (3-mc) induced on fibrosarcoma. a total of 135 adult male mouse (mus musculus) albino,2-3 months old and weighting 20±2.0 g was used in this study. mice in each group were divided 15 consisting of 9 individual. the first group was kept as a negative control group. the second group received subcutaneous injection of 0.2 ml sesame oil,and the third group was given subcutaneously 3-mc (1 mg/0.2 ml sesame oil). the 4th,5th and 6th groups recived 0.1% cysteamine,0.1% putrescine and 0.1% cysteamine + 0.1% putrescine mix with drinking water ad libitum respectively. the 7th,8th and 9th groups were injected with 0.2 ml of 3-mc solution. after 1 month 0.1% cysteamine,0.1% putrescine and 0.1% cysteamine + 0.1% putrescine combinations were administrated in drinking water to 7th,8th and 9th groups respectively. after 1 year of all experiments mice tissues were evaluated morphologic and histopathologically. as a result were respectively demonstrated protective effect of putrescine,cysteamine+putrescine and cysteamin against 3-mc induced fibrosarcoma.