The protective role of silymarine on selenite-induced cataract in rabbit model [Tavşan modelinde silymarinin selenit ile oluşturulmuş katarakt üzerine koruyucu rolü]

The study was designed to investigate silymarine as preventive agent in selenite-induced cataract in rabbits. eighteen rabbits were concluded and divided equally into negative control (i),positive control (ii) and test (iii) groups,each 6. after clinical and ophthalmoscope,bio-microscope slit lamp equipped with a digital camera and ultrasonographical examinations of rabbits' eyes,selenite sodium was administered subcutaneously on the neck in all rabbits at day 0 of the study. after induction of anesthesia,lateral recumbency and making a pore in globe 0.1ml of saline solution 0.9% in group ii and 0.1ml of silymarine were injected into vitreous in group iii. any agent did not administrate in group i. selenite sodium was injected in days third and sixth in all rabbits subcutaneously. the bio-microscopic slit lamp study showed grade one and two cataract in day 4 and 8,and grade three in day 11 in all rabbits in group i and ii. in group iii,three rabbits on the eighth day and four until the end of the eleventh day presented grade one cataract. anterior lens capsule thickness was less in group iii in comparison to group i and ii,and posterior capsule thickness in group iii was significant statistically by ultrasonography on day 20 and the anterior-posterior lens diagonal length in the experimental group comparing to the control groups was longer significantly. selenite sodium showed cataractogenic character and silymarine as probable protective role on selenite -induced cataract in rabbit model.