Serum ceruloplasmin,paraoxanase and nitric oxide levels in akkaraman sheep with high nitrate in drinking water [İçme sulari{dotless}nda yüksek nitrat bulunan akkaraman koyunlarda serum seruloplazmin,paraoksanaz ve nitrik oksit düzeyleri]

The data obtained by ankara refik saydam hifzisihha center,in the scope of the routine monitoring works carried out at nevşehir/hacibektaş regions' wells were found high nitrate content. nitrate values of three well water sampling points in the province of yalnizaǧil obtained from the monitoring works 69.7 mg/l,56.8 mg/l and 59.4 mg/l nitrate ratios were found. the purpose of this study is to investigate the changes of serum ceruloplasmin,paraoxonase and nitric oxide levels in akkaraman sheep with high nitrate in drinking water. in this study,akkaraman sheep which is the animal population of region were used as material. the blood samples collected from akkaraman sheep were analyzed in terms of ceruloplasmin,paraoxonase and nitric oxide levels by spectrophotometry. serum ceruloplasmin,paraoxonase and nitric oxide levels was found,10.68±0.14 um; 10.80±0.32 um: 151.36±14.95 u/ml,142.57±17.85 u/ml and 2.01±0.30 u/ml,0.99±0.11 u/ml by means of control and study groups respectively. statistically,serum ceruloplasmin levels were significantly lower in the study group compared with control group. in addition,although paraoxanase and nitric oxide levels in serum were not show significant differences between groups,measurments reveal that paraoxanase levels were lower in study groups. these results suggest that adverse effects of nitrates on akkaraman sheep occur at concentrations present in the fields.