Mitotane-induced hypoadrenocorticism in a dog with hyperadrenocorticism [Hiperadrenokortisizmli bir köpekte mitotan kullanımına bağlı gelişen hipoadrenokortisizm]

A 5-year-old,terrier breed dog having the complaints of anestrus,polyuria,polydipsia and alopecia referred to small animal veterinary teaching hospital. paraclinical and clinical assessments confirmed the diagnosis of pituitary-dependent hyperadrenocorticism and mitotane (25mg/kg bid 5 days) prescribed. the dog was presented to clinic with the signs of vomiting,ataxia and weakness after two weeks. the owner reported that mitotane therapy continued for 14 days without decreasing the dosage contrary to what is describe. routin blood work and basal cortisol concentration revealed severe hypoglycemia and hypocortisolemia. methylprednisolone acetate and supportive therapy were initiated. the dog died after three weeks according to owner’s information. this case report emphasized that one of the possible complication of mitotane therapy is hypoadrenocorticism. © 2015,veteriner fakultesi dergisi. all rights reserved.