The use of decellularized animal tissues in regenerative therapies [Hücrelerinden arındırılmış hayvansal dokuların rejeneratif tedavilerde kullanımı]

Human adipose-derived mesenchymal stem cells are nonhematopoietic cells found in the adipose tissue that have multipotent characteristics. human adipose-derived mesenchymal stem cells have ability to differentiate into multiple lineages,including osteogenic,adipogenic and chondrogenic phenotypes. because of their high degree of plasticity and ease of isolation,they have a great potential for tissue engineering and regenerative medicine applications. tissue engineering,using cells,soluble matriks-bound factors and supporting scaffolds,is a promising approach for regeneration,repairing and replacement of malfunctioning tissues and organs. three-dimensional scaffolds are essential to serve as an adhesive substrate for the transplanted cells and a physical support to guide the formation of new tissues or organs. particularly,the use of extracellular matrices prepared by decellularized whole tissue and organ as three-dimensional constructs have drawn increasing attention as a tissue engineering strategy. in this context,it is expected that investigating the cellular behaviour of human adipose-derived mesenchymal stem cells on decellularized whole tissue and organ will have a positive impact on regenerative medicine. this review offers a current perspective about decellularization of animal tissues,stem cells’ behaviors on obtained matrices and potential use of these matrices in human and/or animal clinic. © 2015,veteriner fakultesi dergisi. all rights reserved.