Serum and saliva sialic acid and oxidative stress parameters changes in bulls with foot and mouth disease [Şap hastalıklı boğalarda serum ve salya sialik asit ve oksidatif stres parametrelerindeki değişiklikler]

The study comprised of 12 bulls,aged between 18-36 months,determined severe symptoms of foot-and-mouth disease (fmd) and 10 clinically healthy bulls of similar age. serum and saliva total sialic acid (sa),malondialdehyde (mda),glutathione (gsh) and nitric oxide (no) levels were measured. in this study were determined acute fever,anorexia,vesicular lesions in the mouth and feet of infected animals with consequent excessive salivation,lameness and reduced productivity as clinical signs. mean serum sa,mda,gsh and no levels were 503.96±21.43 mg/l,31.82±3.43 μmol/l,63.43±2.92 mg/dl,and 6.49±0.36 nmol/l in healthy bulls and 862.01±17.35 mg/l,82.49±9.90 μmol/l,24.96±2.32 mg/dl,and 13.89±0.53 nmol/l in fmd cases,respectively. mean saliva sa,mda,gsh and no levels were 75.98±10.25 mg/l,1.06±0.17 μmol/l,0.67±0.05 mg/dl,and 1.44±0.14 nmol/l in healthy bulls and 156.49±14.07 mg/l,1.81±0.15 μmol/l,0.34±0.03 mg/dl,and 2.44±0.16 nmol/l in fmd cases,respectively. the differences between the two groups were statistically significant (p<0.001 and p<0.01). mean serum and saliva gsh level was lower in fmd while all other parameters were considerable high. as a result,showing signs of foot and mouth disease in bulls,serum and saliva in sialic acid and oxidative stress parameters are affected very significantly. © 2016,veteriner fakultesi dergisi. all rights reserved.