Age related histopathological and immunohistochemical changes in horse brains [Atlarda yaşla ilgili beyinde oluşan histopatolojik ve immunohistokimyasal değişiklikler]

The aim of this study was to investigate age dependent pathological changes in horse brains. in the study,10 mature horses aged between 10-16 years,13 old horses aged between 17-21 years old and 7 young horses between 4-7 years old were examined macroscopically,histopathologically and immunohistohemically. as compared young horse brains; ventricular dilatation,satellitosis,neuronal vacuolization,status spongiosis,ventricular dilatation and ependymal undulation,calcium deposits and axonal swellings were seen in old horse brains. immunohistochemical staining was obtained with glial fibrillary acidic protein (gfap),2’,3’-cyclic nucleotide 3’-phosphodiesterase (cnpase),neuron-specific enolase (nse),β-amyloid protein (aβ) antibodies to indicate age related changes in brains. � 2016,veteriner fakultesi dergisi. all rights reserved.