Fresh garlic amelioration of high-fat-diet induced fatty liver in albino rats

Objective: to observe the effect of fresh garlic on high-fat-diet-induced fatty liver changes. methods: the experimental study was conducted at the jinnah postgraduate medical centre,karachi,from october to november 2008,and comprised adult albino rats weighing 200-240g each. the rats were divided into 5 groups according to dietary regimen for eight weeks each. group a received control diet; group b received high saturated fat diet; group c received high unsaturated fat diet; group d received high saturated fat diet with fresh garlic; and group e received high unsaturated fat diet with garlic for 8 weeks. liver tissue slides were stained with oil red-o and haematoxylin and periodic acid-schiff-haematoxylin. results: the 50 rats in the study were divided into five groups of 10(20%) each. there was marked deposition of fat in hepatocyte along with marked decrease in glycogen content in liver of rats in groups b and c,with group b showing more marked changes. the changes in fat and glycogen content were reversed and ameliorated close to group a in rats belonging to groups d and e. conclusion: fresh garlic minimised the high-fat-diet-induced fatty liver changes in rats. © 2015,pakistan medical association. all rights reserved.