Role of vitamin E in preventing arteriohyalinization in kidneys of streptozotocin induced diabetic mice

Objective: to evaluate the role of vitamin e on the arteriolar hyalinisation in kidneys of diabetic mice. methods: the laboratory-based randomised control trial was conducted at the department of anatomy,army medical college,rawalpindi,in collaboration with national institute of health,islamabad,from november 2009 to november 2010. adult female balb/c mice were randomly divided into three groups. group a served as control group. group b was made diabetic by the intraperitoneal injection of streptozotocin. group c received streptozotocin injection and was fed with vitamin e (alphatocopherol) supplemented diet. after 12 weeks,the animals were sacrificed and their kidneys were removed for histomorphological study. spss 16 was used for statistical analysis. results: diabetes caused significant histomorphological changes in arteriole of kidneys of experimental group b compared to control group a (p>0.05),but these changes were prevented in group c. in experimental group b,2(20%) animals had arteriolar hyalinisation of score 1,while score 2 was revealed in 8(80%) animals. experimental group c showed no hyalinisation in any arteriole. conclusion: vitamin e prevents the arteriohyalinization in kidneys of mice with stz induced diabetes. © 2015,pakistan medical association. all rights reserved.