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Role of L-carnitine in male infertility
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نویسنده
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Ahmed Danish Haseen ,Karira Khemomal Asudo ,Jagdesh ,Ahsan Shahid
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منبع
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journal of the pakistan medical association - 2011 - دوره : 61 - شماره : 8 - صفحه:732 -736
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چکیده
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Objective: to test the hypothesis that the free l-carnitine helps in maintaining normal fertility. methods: the present descriptive study was designed to show comparison of seminal free l-carnitine and sperm quality. case controlled convenient sampling was used to assess infertile male subjects from fertile. a total of 61 adult males were selected by consent, and were categorized as fertile and infertile on the basis of history and semen analysis. subjects were selected from infertility clinic, reproductive health services centre of jinnah postgraduate medical centre, karachi. subject's with history of pelvic surgery, or suffering from diabetes mellitus, thyroid diseases or using steroids, antihypertensives and antipsychotics drugs were excluded from the study. groups were compared using student's t-test and p < 0.05 was considered as statistically significant. results: the mean values of sperm count, total motility and normal morphology of asthenospermic and oligoasthenoteratospermic were found significantly (p<0.05) lower when compared with fertile (control). when levels of seminal free l-carnitine were compared among groups, the result showed that infertile subjects had significantly lower (p<0.001) when compared to fertile subjects with lowest concentration in azoospermic group. conclusion: the results of this study suggested that l-carnitine level in seminal plasma plays an essential role in maintaining male fertility. however larger studies on pakistani population with this approach are warranted.
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کلیدواژه
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Male ,Infertility ,L-carnitine
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آدرس
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Hamdard College of Medicine & Dentistry, Department of Biocemistry, Pakistan, Jinnah Postgraduate Medical Centre, Basic Medical Sciences Institute, Department of Biochemistry, Pakistan, Muhammad Medical College, Department of Biochemistry, Pakistan, Baqai Institute of Diabetes & Endoccrinology, Pakistan
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Authors
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Jagdesh
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