Acacia Nilotica Leave Extract and Glyburide: Comparison of Fasting Blood Glucose, Serum Insulin, β-Thromboglubulin Levels and Platelet Aggregation in Streptozotocin Induced Diabetic Rats

Objectives: to evaluate the hypoglycaemic and anti-platelet aggregation effect of aqueous methanol extract of acacia nilotica (an) leaves compared with glyburide on streptozotocin induced diabetic rats.methods: diabetes mellitus was induced in 90 out of 120 albino rats by administering 50 mg/kg body weight (b.w) streptozotocin and was confirmed by measuring fasting blood glucose level >200 mg/dl on 4th post-induction day.the rats were equally divided into 4 groups, a (normal control), b (diabetic control), c (diabetic rats treated with an extract) and group d (diabetic rats treated with glyburide). the rats of group c and d were given 300 mg/kg b.w an extract and 900 ?gm/kg b.w glyburide respectively for 3 weeks. blood glucose was measured by glucometer, platelet aggregation by dia-med method and insulin and β-thromboglobulin by elisa technique.results: a significant increase (p<0.05) in fasting blood glucose, β-thromboglobulin and platelet aggregation and a significant decrease (p<0.05) in insulin levels was observed in streptozotocin induced diabetic rats than the normal controls. the rats treated with an extract and glyburide showed a significant decrease (p<0.05) in fasting blood glucose and increase (p<0.05) in insulin levels than the diabetic control rats. however, the levels in both the treatment groups remained significantly different than the normal controls. a significant decrease (p<0.05) in β-thromboglobulin levels was seen in diabetic rats treated with glyburide than the diabetic control rats and diabetic rats treated with an extract.conclusions: an leaves extract result into hypoglycaemic and anti-platelet aggregation activity in diabetic rats as that of glyburide.