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The structural changes of the rat's lung induced by intraperitoneal injection of 5-fluorouracil
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نویسنده
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Al-Hamdany Muna Zuhair ,Al-Hubaity Abduljabbar Yasin Muhammed
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منبع
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journal of the pakistan medical association - 2014 - دوره : 64 - شماره : 7 - صفحه:734 -738
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چکیده
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Objective: to record the main structural changes in the rat's lung induced by administration of 5-fluorouracil. methods: the case-control study was conducted at college of medicine, mosul, iraq, from december 2012 to june 2013. two groups of 6 rats each were used. the experimental group was given 20mg of 5-fluorouracil in 2ml normal saline per kg body weight by intraperitoneal injection for 7 consecutive days, while the other group was given 2ml normal saline per kg body weight intraperitoneally for 7 days and served as the control group. specimens of lung tissue of the two groups were taken and prepared for light microscopic examination. result: structural changes were found in the experimental (5-fluorouracil) group compared to the controls, including abnormal alveolar duct, sac, and terminal bronchioles with emphysematous changes in most of the alveoli in addition to peribronchiolitis, perivasculitis, inflammatory cells infiltration and interstitial fibrosis. conclusion: 5-fluorouracil has toxic effects on the lung tissue resulting in emphysema and interstitial fibrosis.
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کلیدواژه
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5-fluorouracil ,Rat ,Lung ,Emphesema ,Interstitial fibrosis.
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آدرس
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University of Mosul, College of Medicine, Department of Anatomy, Iraq, University of Mosul, College of Medicine, Department of Anatomy, Iraq
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پست الکترونیکی
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alhubaity50@yahoo.com
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Authors
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