An alternative treatment model: the combination therapy of narrow band ultraviolet B phototherapy and tacrolimus ointment 0,1% in biphasic amyloidosis

Primary localized cutaneous amyloidosis (plca) is caused by the extracellular deposition of amyloid material in the skin without other cutaneous or systemic organ involvement . pcla is classified into lichen, macular,and nodular amyloidosis. macular amyloidosis and lichen amyloidosis are named as biphasic amyloidosis when they are concurrently seen in a patient. the treatment of this disease is insufficient,even if there are several alternatives for treatment. here we present a case of biphasic amyloidosis that responded well to topical tacrolimus ointment 0,1% plus narrow band ultraviolet b (nbuvb) treatment treatment to be able to generate a new treatment alternative model. with this case presentation, by reviewing of the treatment modalities of this rarely observed case, will contribute to the solution of the disease.