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   Tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction and unstable angina  
   
نویسنده Habib Syed Shahid ,Abdel Gader Abdel Galil Mohamad ,Kurdi Mohammad Ibrahim ,Suriya Mohammad Owais ,Al Aseri Zohair
منبع journal of the pakistan medical association - 2012 - دوره : 62 - شماره : 7 - صفحه:682 -685
چکیده    Objective: to compare levels of tissue plasminogen activator and plasminogen activator inhibitor-1 levels in patients with acute myocardial infarction and unstable angina in order to understand the use of high sensitivity c-reactive protein (hscrp), coagulation and fibrinolysis markers for cardiovascular risk assessment. methods: the cross-sectional case-control study compared circulating concentrations of high sensitivity c reactive protein (hscrp), fibrinogen, tissue-type plasminogen activator (tpa), and plasminogen activator inhibitor-1 (pai-1) between patients of acute myocardial infarction (ami) (n = 67), unstable angina pectoris (ua) (n = 35) and healthy control subjects (n = 39) at the king khalid university hospital, riyadh, saudi arabia, from june 2006 to august 2007. results: the patients had significantly higher hscrp (1.06 ± 0.11 vs 0.52 ± 0.14, p<0.01), fibrinogen (426.21 ± 24.09 vs 329.32 ± 13.93, p<0.05), pai-1 (44.02 ± 6.05 vs19.35 ± 3.94, p<0.01) and tpa (12.31 ± 1.16 vs 9.49 ± 0.86, p<0.05) compared to the controls. fibrinogen (329.32 ± 13.93) and pai-1 (19.35 ± 3.94) were higher in both angina and infarction groups compared to the healthy subjects (p<0.01). between the two categories of patients the difference between fibrinogen (449.60 ± 52.98 vs 419.46 ± 23.42) and pai-1 (52.00 ± 17.34 vs 43.19 ± 6.10) levels were non-significant. also, the difference in tpa levels between the controls and angina patients was nonsignificant (9.49 ± 0.86 vs 9.91 ± 1.24 p>0.05). it was higher in infarction patients (14.79 ± 3.14) compared to angina patients and the controls, (p<0.05). compared to the controls, hscrp levels were significantly higher in both the patient groups (0.52 ± 0.14, 1.05 ± 0.28, 1.40 ± 0.20, p<0.01). moreover, they were significantly higher in infarction patients than those suffering from angina (p<0.05). conclusions: cad patients had a procoagulant state and presented with higher levels of hscrp compared to the healthy individuals. moreover, there were significant differences in coagulation markers and hscrp between angina and infarction patients.
کلیدواژه Unstable angina ,Acute myocardial infarction ,hsCRP ,Coronary artery disease ,tissue-typeplasminogen activator ,plasminogen activator inhibitor-1.
آدرس King Saud University, College of Medicine, King Khalid University Hospital, Department of Physiology, Saudi Arabia, King Saud University, College of Medicine, King Khalid University Hospital, Department of Physiology, Saudi Arabia, King Saud University, King Khalid University Hospital, Department of Cardiology, Saudi Arabia, King Saud University, King Khalid University Hospital, Department of Emergency Medicine, Saudi Arabia, King Saud University, King Khalid University Hospital, Department of Emergency Medicine, Saudi Arabia
 
     
   
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