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Correlation of human epidermal growth factor receptor 2 (HER-2/neu) receptor status with hormone receptors Oestrogen Receptor, Progesterone Receptor status and other prognostic markers in breast cancer: an experience at tertiary care hospital in Karachi
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نویسنده
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Mujtaba Shafaq ,Haroon Saroona ,Faridi Naveen ,Lodhi Faisal Rashid
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منبع
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journal of the pakistan medical association - 2013 - دوره : 63 - شماره : 7 - صفحه:854 -857
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چکیده
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Objective: to determine the frequency of human epidermal growth factor receptor 2 (her-2/neu) positivity and to correlate its status in breast cancer patients with other prognostic markers. methods: the comparative cross-sectional study was conducted at the department of histopathology, liaquat national hospital, karachi, from january 1 to october 31, 2010. it included all specimens of mastectomy and lumpectomy with axillary tissue. incisional, trucut and wedge biopsies as well as all non-epithelial tumours were excluded. all samples were processed as per standard guidelines and were evaluated by immunohistochemistry. spss 10 was used for statistical analysis. results: the age of the 100 cases in the study ranged from 20 to 82 years with a mean of 51±17.6 years. two (2%) of the patients were males. her-2/neu over-expression increased with increasing tumour size, grade, lymph node metastasis and with oestrogen receptor and progesterone receptor negativity. no significant correlation of her-2/neu was seen with the age of patient and with the tumour type.conclusions: the expression of her-2/neu was associated with decrease in oestrogen receptor and progresteronereceptor positivity, and increase in tumour size, high tumour grade and lymph node metastasis.
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کلیدواژه
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Breast carcinoma ,Estrogen receptor ,Progesterone receptor ,HER-2/neu ,C-erb B2.
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آدرس
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Aga Khan University, Liaquat National Hospital, Department of Pathology, Pakistan, Aga Khan University, Department of Pathology & Microbiology, Pakistan, Aga Khan University, Liaquat National Hospital, Department of Pathology, Pakistan, Aga Khan University, Liaquat National Hospital, Department of Pathology, Pakistan
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Authors
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