Effects of osteoformin in the rapid distraction osteogenesis of rabbit mandibles

Objective: to evaluate the effects of osteoformin on mineralisation and quality of the new bone formation during rapid distraction osteogenesis. methods: this multi-centre study was conducted at the karadeniz technical university,middle east technical university and selcuk university. the experimental study was conducted from january 2010 to september 2012 and comprised new-zealand rabbits that were randomly divided into three groups. in group i distraction rate was 1 mm/day while in groups ii and iii distraction rates were 2mm/day and 1 mm/day. in groups i and ii 100µg/kg osteoformin was injected after the latency period. distraction region was evaluated by radiological,histomorphometrical and dual energy x-ray absorptiometry analyses. spss 17 was used for statistical analysis. results: there were 18 rabbits with each of three groups having 6(33.3%). accelerated bone healing was noted in groups i and ii compared with group iii (p<0.05). no significant differences were indicated between groups i and ii (p>0.05). conclusion: local injection of osteoformin was effective in the craniomaxillofacial distraction osteogenesis in rabbits. further experimental studies are recommended before using osteoformin on humans. © 2016,pakistan medical association. all rights reserved.