Effect of HCV on fasting glucose,fasting insulin and peripheral insulin resistance in first 5 years of infection

Objective: to assess the effects of hepatitis c virus infection in the first 5 years on fasting glucose,fasting insulin and peripheral insulin resistance. methods: the case-control study was conducted at the army medical college,rawalpindi,from december 2011 to november 2012,and comprised subjects recruited from a government hospital in rawalpindi. the subjects included known cases of hepatitis c virus infection for at least 5 years,and normal healthy controls. fasting blood samples of all the subjects were collected and analysed for serum fasting insulin and serum fasting glucose levels. homeostatic model assessment-insulin resistance was calculated spss 11 was used for statistical analysis.. results: of the 30 subjects,20(66.6%) were cases,while 10(33.3%) were controls. serum fasting glucose mean level in cases was 89.55±9.53 compared to 84.40±9.80 in the controls (p=0.188). the mean serum fasting insulin in controls was 7.52±3.23 and 6.79±3.30 in cases (p=0.567). homeostatic model assessment-insulin resistance level in controls was 1.60±0.76 and in the cases it was 1.49±0.74 (p=0.695). conclusion: peripheral insulin resistance and development of type 2 diabetes as a complication of hepatitis c virus infection was not likely at least within the first five years of infection. © 2016,pakistan medical association. all rights reserved.