Serum myeloperoxidase (MPO) activity,oxidative and antioxidative parameters in operating room personnel

Objectives: to investigate the effects of occupational exposure to anaesthetic gases on myeloperoxidase activity,oxidative and antioxidative parameters in operating room personnel. methods: the cross-sectional study was conducted at yuzuncu yil university,van,turkey,in may 2011,and comprised equal number of operating room and non-operating room personnel. serum myeloperoxidase activity,sulfhydryl group levels,lipid hydroperoxide levels and catalase activity were determined. spss 11 was used for data analysis. results: there were 64 subjects; 32(50%) each in the two groups. myeloperoxidase activity and lipid hydroperoxide levels were significantly higher in operating room personnel than in the non-operating room personnel (p<0.001; p<0.001),while catalase activity and sulfhydryl group levels were significantly lower (p<0.009; p<0.003). catalase activity negatively correlated with lipid hydroperoxide levels in operating room personnel (r=-0.293; p=0.018). myeloperoxidase activity negatively correlated with sulfhydryl group levels in operating room personnel (r=-0.267; p=0.031). conclusions: operating room personnel exhibited higher oxidative stress,which may be due to the oxidative effect of anaesthetic gases. � 2016,pakistan medical association. all rights reserved.