Comparison of serum anti-mullerian hormone among fertile and infertile normal and diminished ovarian reserve groups

Objective: to compare anti-mullerian hormone among fertile and infertile groups of women in their reproductive age. methods: this case-control study was conducted at the dow university of health sciences in collaboration with civil hospital,karachi,from october 2011 to october 2012,and comprised fertile non-pregnant and infertile women. serum anti-mullerian hormone levels were measured in both the infertile and fertile groups. blood samples to determine anti-mullerian hormone levels were obtained irrespective of their menstrual cycle days. infertile cases were further divided into two subgroups according to serum anti-mullerian hormone levels,into normal ovarian reserve group and diminished ovarian reserve group. spss 18 was used for data analysis. results: of the 100 participants,48(48%) women were fertile controls and 52(52%) were infertile. of the latter,there were 30(57.69%) in the normal ovarian reserve group and 22(42.31%) in the diminished ovarian reserve group. the mean age of the participants was 26±4.026 years (range: 25-35 years). the mean values for the control,normal ovarian reserve and diminished ovarian reserve groups were 1.9±0.16 ng/ml,0.89±0.47 ng/ml and 2.0±0.6 ng/ml,respectively (p=0.001). conclusion: mean concentration of serum anti-mullerian hormone in infertile women with diminished ovarian reserve was significantly lower than that in normal ovarian reserve group and fertile control women. © 2016,pakistan medical association. all rights reserved.