Serum anti-mullerian hormone: Correlation with the ovarian follicular dynamics in healthy mice

Objective: to evaluate the relationship between serum anti-mullerian hormone and follicular dynamics in mice. methods: this experimental study was conducted in november,2014 at the dow university of health sciences,karachi,and comprised laboratory-bred albino mice. they were sacrifised under anaesthesia and blood was collected via cardiac puncture to assess anti-mullerian hormone while ovaries were collected for morphometric analyses. spss 19 was used for data analysis. results: there were 20 mice with a mean weight of 25±1.89 grams,while weight of the ovaries obtained from these mice was 9.6±0.92mg. the mean serum anti-mullerian hormone was 29.89±9.7ng/ml. on average,there were 87.8+13.54 primordial follicles,51.85±8.36 primary,20.35±5.57 secondary,11.30±3.38 early antral and 3.05 ± 1.27 late antral follciles (p<0.001; p=0.06). conclusion: association of anti-mullerian hormone with follicle dynamics reflected its role as a true ovarian reserve marker. its assessment was of great significance in infertile women as well as young patients receiving chemotherapy. © 2016,pakistan medical association. all rights reserved.