The impact of hypertension on lipid parameters in type 2 diabetes

Objective: to study the effect of hypertension on lipid levels in patients with type 2 diabetes mellitus. methods: this prospective,observational study was conducted at 1 mountain medical battalion,bagh,azad kashmir,from may 2012 to april 2015,and comprised adult type 2 diabetics. patients already on lipid-lowering agents,hypothyroidism,nephrotic syndrome,unwilling patients and those who had serum triglycerides>4.5mmol/l were excluded. blood pressure was measured twice in sitting position. amongst hypertensive patients,blood pressure <140/90mmhg reflected good control. serum total cholesterol,triglyceride and high-density lipoproteins were measured using enzymatic calorimetric method. friedewald equation was used to calculate low-density lipoprotein levels.subjects were divided into three groups: those without hypertension; those with hypertension but good blood pressure control; and hypertensives with poor blood pressure control. spss 20 was used for data analysis. results: of the 322 patients,129(40.06%) were women and 193(59.94%) were men. the overall mean age was 51.42�10.93 years. hypertension was seen in 144(44.72%) patients. blood pressure was well controlled in 46(31.94%) hypertensive patients. among patients without hypertension and those with good or poorly controlled blood pressure,the mean values for serum total cholesterol were 181.08� 32.05,186.87� 39.00,185.33� 35.55 mg/dl,triglycerides were 172.57�80.53,187.61�81.42,183.19�74.34 mg/dl,high-density lipoproteins were 40.54�12.36,37.06�8.80,40.15�12.35 mg/dl and low-density lipoproteins were 105.79�29.73,110.81�31.66,106.56�35.16 mg/dl. the number of patients with abnormalities of total cholesterol was 44(26.83%),13(28.26%),33(29.46%),triglycerides was 83(50.61%),30(65.22%),66(58.93%),high-density lipoproteins was 119(72.56%),39(84.78%),93(83.04%) and low-density lipoproteins was 90(54.88%),29(63.04%) and 59(52.68%),respectively. conclusion: hypertension did not worsen diabetic dyslipidaemia. � 2016,pakistan medical association. all rights reserved.