Frequency of CYP2D6*10 genotypes in Pakistani breast cancer patients taking adjuvant tamoxifen

Objective: to investigate the frequency of cytochrome p2d6*10 in breast cancer patients. methods: this retrospective study was conducted at the nuclear medicine,oncology and radiotherapy institute,islamabad,and the combined military hospital,rawalpindi,pakistan,and comprised medical records of breast cancer patients from january 2000 to september 2013. pre- and post-menopausal women with diagnosed breast cancer who were advised 20mg/day of tamoxifen as adjuvant therapy were included. the frequency of the cytochrome was determined using polymerase chain reaction-restriction fragment length polymorphism analysis. results: of the 232 participants,25(10.8%) had stage i disease,127(54.7%) had stage ii and 80(34.5%) had stage iii disease. the overall mean age was 46.9�9.9 years. the allele frequency of cytochrome cyp2d6*1 was 431(93%) and that of cyp2d6*10 was 33(7 %). pakistanis differed significantly from the asian populations and other ethnic groups in the distribution of the allele cytochrome,but its frequency was comparable to south indians. conclusion: the frequency of cyp2d6*10 allele in pakistani breast cancer women was comparable to the south indians,but was significantly lower than other populations. � 2016,pakistan medical association. all rights reserved.