Stages of chronic kidney disease and soluble transferrin receptor (sTfR),ferritin,ratio

Objective: to assess the ratio of soluble transferrin receptor to ferritin in different stages of chronic kidney disease. methods: this case-control study was conducted at the aga khan university hospital and the jinnah postgraduate medical centre,karachi,from january to september 2014,and comprised chronic kidney disease patients and healthy controls. group 1 comprised controls,whereas groups 2,3 and 4 had patients based on their mean glomerular filtration rate. spss 19 was used for data analysis. results: of the 170 participants,126(74.1%) were cases and 44(25.9%) were controls. the overall mean age was 55.87±3.48 years and the mean body mass index was 24.25±2.9 kg/m2. decreased levels of iron and haemoglobin were observed in cases compared to controls (p<0.001),while high serum ferritin was seen in cases compared to the controls (p<0.001). correspondingly,the soluble transferrin receptor-to-ferritin ratio was significantly decreased in groups 2,3 and 4 (p<0.001). conclusion: the ratio of soluble transferrin receptor to ferritin was lower in higher stages of chronic kidney disease. © 2017,pakistan medical association. all rights reserved.