Comparison of foeto-maternal outcome in pregnant women with hepatitis E — A review of 12 years

Objective: to compare adverse maternal and foetal outcome in pregnant women with hepatitis e immunoglobulin m reactive versus non-reactive. methods: this retrospective study was conducted at the aga khan university hospital,karachi,and comprised records of pregnant patients at any gestational age with clinical and biochemical evidence of hepatitis e from january 2002 and december 2014. maternal and perinatal outcome of the subjects were analysed. spss 20 was used for data analysis. results: out of the 200 subjects,168(84 %) were hepatitis e immunoglobulin m reactive and 32(16%) were non-reactive. the overall mean age was 26.7±4.5 years. also,12(7%) patients in the immunoglobulin m reactive group were admitted to intensive care unit compared to no one from the non-reactive group. similarly fulminant hepatic failure was seen in 12(7.1%) patients in the immunoglobulin m reactive group compared to no one in the other group. post-partum haemorrhage was more frequent in the immunoglobulin m reactive group compared to the non-reactive group. there were 5(3%) maternal deaths in the reactive group compared to no death in the other group. moreover,34(20.2%) neonates of the immunoglobulin m reactive group needed neonatal intensive care unit admission compared to none in the non-reactive group. there were 4(2.4%) neonatal deaths in the reactive group. conclusion: participants in the immunoglobulin m reactive group had a higher percentage of adverse foeto-maternal outcomes compared to the non-reactive group. © 2017,pakistan medical association. all rights reserved.