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Association of vitamin D binding protein polymorphism with risk of type 2 diabetes mellitus in a Pakistani urban population: A case control study
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نویسنده
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iqbal k. ,islam n. ,azam i. ,asghar a. ,mehboobali n. ,iqbal m.p.
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منبع
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journal of the pakistan medical association - 2017 - دوره : 67 - شماره : 11 - صفحه:1658 -1663
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چکیده
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Objective: to assess if genotypes/diplotypes of vitamin d binding protein have any association with type 2 diabetes mellitus. methods: this case-control study was conducted from january 2013 to july 2015 at the endocrinology clinics of the aga khan university hospital,karachi,and comprised adult patients with type 2 diabetes and their age- and gendermatched healthy controls. venous blood was obtained and assessed for serum/plasma 25 hydroxyvitamin d,parathyroid hormone,calcium,alkaline phosphatase and creatinine. deoxyribonucleic acid was isolated and genotyping was done by polymerase chain reaction-restriction fragment length polymorphism procedures. results: of the 330 participants,there were 165(50%) cases and as many controls. there were 116(70.3%) males and 49(29.7%) females in each group. the mean age of the patients was 48.82±9.23 years and that of the controls was 46.27±8.77 years (range: 22-70 years) (p=0.010) mean serum concentration of 25 hydroxy vitamin d was significantly higher among the patients compared to the controls (p<0.001),but not significantly different by genotypes or diplotypes (p>0.05). multiple conditional logistic regression revealed an association of group-specific 1-2 genotype with patients when adjusted for age,body mass index,and serum levels of 25 hydroxy vitamin d with matched adjusted odds ratio (95% confidence interval) being 3.1(1.22-7.88). conclusion: group-specific 1-2 genotype of vitamin d binding protein gene was associated with the risk of type 2 diabetes. © 2017,pakistan medical association. all rights reserved.
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کلیدواژه
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Diabetes mellitus; Gc protein; Gene polymorphism; Vitamin D binding proteins
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آدرس
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department of biological and biomedical sciences,aga khan university,karachi, Pakistan, department of medicine,aga khan university,karachi, Pakistan, department of community health sciences,aga khan university,karachi, Pakistan, department of medicine,aga khan university,karachi, Pakistan, department of biological and biomedical sciences,aga khan university,karachi, Pakistan, department of biological and biomedical sciences,aga khan university,karachi, Pakistan
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Authors
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