Effect of beta-alanine supplementation on the onset of blood lactate accumulation (OBLA) during treadmill running: Pre/post 2 treatment experimental design

Background: β-alanine (βa) has been shown to improve performance during cycling. this study was the first to examine the effects of βa supplementation on the onset of blood lactate accumulation (obla) during incremental treadmill running.methods: seventeen recreationally-active men (mean ± se 24.9 ± 4.7 yrs,180.6 ± 8.9 cm,79.25 ± 9.0 kg) participated in this randomized,double-blind,placebo-controlled pre/post test 2-treatment experimental design. subjects participated in two incremental treadmill tests before and after 28 days of supplementation with either βa (6.0 g·d-1)(βa,n = 8) or an equivalent dose of maltodextrin as the placebo (pl,n = 9). heart rate,percent heart rate maximum (%hrmax),%vo2max@obla (4.0 mmol.l-1blood lactate concentration) and vo2max(l.min-1) were determined for each treadmill test. friedman test was used to determine within group differences; and mann-whitney was used to determine between group differences for pre and post values (p < 0.05).results: the βa group experienced a significant rightward shift in hr@obla beats.min-1(p < 0.01) pre/post (161.6 ± 19.2 to 173.6 ± 9.9) but remained unchanged in the pl group (166.8 ± 15.8 to 169.6 ± 16.1). the %hrmax@obla increased (p < 0.05) pre/post in the βa group (83.0% ± 9.7 to 88.6% ± 3.7) versus no change in the pl group (86.3 ± % 4.8 to 87.9% ± 7.2). the %vo2max@obla increased (p < 0.05) in the βa group pre/post (69.1 ± 11.0 to 75.6 ± 10.7) but remained unchanged in the pl group (73.3 ± 7.3 to 74.3 ± 7.3). vo2max(l.min-1) decreased (p < 0.01) in the βa group pre/post (4.57 ± 0.8 to 4.31 ± 0.8) versus no change in the pl group (4.04 ± 0.7 to 4.18 ± 0.8). body mass kg increased (p < 0.05) in the βa group pre/post (77.9 ± 9.0 to 78.3 ± 9.3) while the pl group was unchanged (80.6 ± 9.1 to 80.4 ± 9.0).conclusions: βa supplementation for 28 days enhanced sub-maximal endurance performance by delaying obla. however,βa supplemented individuals had a reduced aerobic capacity as evidenced by the decrease in vo2maxvalues post supplementation. © 2010 jordan et al; licensee biomed central ltd.