Effects of carbohydrates-BCAAs-caffeine ingestion on performance and neuromuscular function during a 2-h treadmill run: a randomized,double-blind,cross-over placebo-controlled study

Background: carbohydrates (chos),branched-chain amino acids (bcaas) and caffeine are known to improve running performance. however,no information is available on the effects of a combination of these ingredients on performance and neuromuscular function during running.methods: the present study was designed as a randomized double-blind cross-over placebo-controlled trial. thirteen trained adult males completed two protocols,each including two conditions: placebo (pla) and sports drink (spd: chos 68.6 g.l -1,bcaas 4 g.l -1,caffeine 75 mg.l -1). protocol 1 consisted of an all-out 2 h treadmill run. total distance run and glycemia were measured. in protocol 2,subjects exercised for 2 h at 95% of their lowest average speeds recorded during protocol 1 (whatever the condition). glycemia,blood lactate concentration and neuromuscular function were determined immediately before and after exercise. oxygen consumption (vo2),heart rate (hr) and rate of perceived exertion (rpe) were recorded during the exercise. total fluids ingested were 2 l whatever the protocols and conditions.results: compared to pla,ingestion of spd increased running performance (p = 0.01),maintained glycemia and attenuated central fatigue (p = 0.04),an index of peripheral fatigue (p = 0.04) and rpe (p = 0.006). maximal voluntary contraction,v̇ o2,and hr did not differ between the two conditions.conclusions: this study showed that ingestion of a combination of chos,bcaas and caffeine increased performance by about 2% during a 2-h treadmill run. the results of neuromuscular function were contrasted: no clear cut effects of spd were observed.trial registration: clinicaltrials.gov,http://www.clinicaltrials.gov,nct00799630. © 2011 peltier et al; licensee biomed central ltd.