The effects PCSO-524®,a patented marine oil lipid and omega-3 PUFA blend derived from the New Zealand green lipped mussel (Perna canaliculus),on indirect markers of muscle damage and inflammation after muscle damaging exercise in untrained men: A randomized,placebo controlled trial

Background: the purpose of the present study was to evaluate the effects of pcso-524®,a marine oil lipid and n-3 lc pufa blend,derived from new zealand green- lipped mussel (perna canaliculus),on markers of muscle damage and inflammation following muscle damaging exercise in untrained men. methods: thirty two untrained male subjects were randomly assigned to consume 1200 mg/d of pcso- 524® (a green-lipped mussel oil blend) or placebo for 26 d prior to muscle damaging exercise (downhill running),and continued for 96 h following the muscle damaging exercise bout. blood markers of muscle damage (skeletal muscle slow troponin i,stni; myoglobin,mb; creatine kinase,ck),and inflammation (tumor necrosis factor,tnf-α),and functional measures of muscle damage (delayed onset muscle soreness,doms; pressure pain threshold,ppt; knee extensor joint range of motion,rom; isometric torque,mvc) were assessed pre- supplementation (baseline),and multiple time points post-supplementation (before and after muscle damaging exercise). at baseline and 24 h following muscle damaging exercise peripheral fatigue was assessed via changes in potentiated quadriceps twitch force (δqtw,pot) from pre- to post-exhaustive cycling ergometer test in response to supra-maximal femoral nerve stimulation. results: compared to placebo,supplementation with the green-lipped mussel oil blend significantly attenuated (p<0.05) stni and tnf-α at 2,24,48,72 and 96 h.,mb at 24,48,72,96 h.,and ck-mm at all-time points following muscle damaging exercise,significantly reduced (p<0.05) doms at 72 and 96 h post-muscle damaging exercise,and resulted in significantly less strength loss (mvc) and provided a protective effect against joint rom loss at 96 h post- muscle damaging exercise. at 24 h after muscle damaging exercise perceived pain was significantly greater (p<0.05) compared to baseline in the placebo group only. following muscle damaging exercise δqtw,pot was significantly less (p<0.05) on the green-lipped mussel oil blend compared to placebo. conclusion: supplementation with a marine oil lipid and n-3 lc pufa blend (pcso-524®),derived from the new zealand green lipped mussel,may represent a useful therapeutic agent for attenuating muscle damage and inflammation following muscle damaging exercise. © mickleborough et al.