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   Effects of protein type and composition on postprandial markers of skeletal muscle anabolism,adipose tissue lipolysis,and hypothalamic gene expression  
   
نویسنده mobley c.b. ,fox c.d. ,ferguson b.s. ,pascoe c.a. ,healy j.c. ,mcadam j.s. ,lockwood c.m. ,roberts m.d.
منبع journal of the international society of sports nutrition - 2015 - دوره : 12 - شماره : 1
چکیده    Background: we examined the acute effects of different dietary protein sources (0.19 g,dissolved in 1 ml of water) on skeletal muscle,adipose tissue and hypothalamic satiety-related markers in fasted,male wistar rats (~250 g). methods: oral gavage treatments included: a) whey protein concentrate (wpc,n = 15); b) 70:30 hydrolyzed whey-to-hydrolyzed egg albumin (70 w/30e,n = 15); c) 50 w/50e (n = 15); d) 30 w/70e (n = 15); and e) 1 ml of water with no protein as a fasting control (ctl,n = 14). results: skeletal muscle analyses revealed that compared to ctl: a) phosphorylated (p) markers of mtor signaling [p-mtor (ser2481) and p-rps6 (ser235/236)] were elevated 2-4-fold in all protein groups 90 min post-treatment (p < 0.05); b) wpc and 70 w/30e increased muscle protein synthesis (mps) 104% and 74% 180 min post-treatment,respectively (p < 0.05); and c) 70 w/30e increased p-ampkα (thr172) 90 and 180-min post-treatment as well as pgc-1α mrna 90 min post-treatment. subcutaneous (sq) and omental fat (omat) analyses revealed: a) 70 w/30 w increased sq fat phosphorylated hormone-sensitive lipase [p-hsl (ser563)] 3.1-fold versus ctl and a 1.9-4.4-fold change versus all other test proteins 180 min post-treatment (p < 0.05); and b) wpc,70 w/30e and 50 w/50e increased omat p-hsl 3.8-6.5-fold 180 min post-treatment versus ctl (p < 0.05). 70 w/30e and 30 w/70e increased hypothalamic pomc mrna 90 min post-treatment versus ctl rats suggesting a satiety-related response may have occurred in the former groups. however,there was a compensatory increase in orexigenic agrp mrna in the 70 w/30e group 90 min post-treatment versus ctl rats,and there was a compensatory increase in orexigenic npy mrna in the 30 w/70e group 90 min post-treatment versus ctl rats. conclusions: higher amounts of whey versus egg protein stimulate the greatest post-treatment anabolic skeletal muscle response,though test proteins with higher amounts of wph more favorably affected post-treatment markers related to adipose tissue lipolysis. © 2015 mobley et al.
کلیدواژه Egg protein; Hydrolyzed protein; Lipolysis; Muscle protein synthesis; Whey protein
آدرس school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States, school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States, school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States, school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States, school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States, school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States, 4life research usa,llc,sandy,ut, United States, school of kinesiology,molecular and applied sciences laboratory,auburn university,301 wire road,office 286,auburn,al 36849, United States
 
     
   
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