Twelve weeks supplementation with an extended-release caffeine and ATP-enhancing supplement may improve body composition without affecting hematology in resistance-trained men

Background: increased atp levels may enhance training-induced muscle accretion and fat loss,and caffeine is a known ergogenic aid. a novel supplement containing ancient peat and apple extracts has reported enhanced mitochondrial atp production and it has been coupled with an extended-release caffeine. therefore,the purpose of this investigation was to determine the effects of this supplement on body composition when used in conjunction with 12 weeks of resistance training. methods: twenty-one resistance-trained subjects (27.2 ± 5.6y; 173.5 ± 5.7 cm; 82.8 ± 12.0 kg) completed this study. subjects supplemented daily with either 1 serving of the supplement (trt),which consisted of 150 mg ancient peat and apple extracts,180 mg blend of caffeine anhydrous and pterostilbene-bound caffeine,and 38 mg b vitamins,or an equal-volume,visually-identical placebo (pla) 45 min prior to training or at the same time of day on rest days. supervised resistance training consisted of 8 weeks of daily undulating periodized training followed by a 2-week overreach and a 2-week taper phase. body composition was assessed using dexa and ultrasound at weeks 0,4,8,10,and 12. vital signs and blood markers were assessed at weeks 0,8,and 12. results: significant group x time (p < 0.05) interactions were present for cross-sectional area of the rectus femoris,which increased in trt (+1.07 cm2) versus pla (-0.08 cm2),as well as muscle thickness (trt: +0.49 cm; pla: +0.04 cm). a significant group x time (p < 0.05) interaction existed for creatinine (trt: +0.00 mg/dl; pla: +0.15 mg/dl) and estimated glomerular filtration rate (trt: -0.70 ml/min/1.73; pla: -14.6 ml/min/1.73),which remained within clinical ranges,but no other significant observations were observed. conclusions: supplementation with a combination of extended-release caffeine and ancient peat and apple extracts may enhance resistance training-induced skeletal muscle hypertrophy without adversely affecting blood chemistry. © 2016 the author(s).