Purification of organic impurities from [18O]H2O used for production of [18F]fluoride as target material [18F]Flor üretiminde hedef olarak kullanilan [18O]H2O içindeki organik safsizliklarin giderimi

[18f]fluoride,which is a positron emitting radioisotopes,is obtained by proton bombardment of [18o]h2o as target material with accelarated protons in particle accelerators. due to its high cost and very low natural abundance of [18o]h2o,using of recyled [18o]h2o after irradiation is more advantageous for many radiopharmaceutical production centers. however,irradiated [18o]h2o contains impurities which result in low [18f] fluoride yields. so,purification of irradiated [18o]h2o and using it for routin production of [18f] is important. in this study,to remove organic impurities from [18o]h2o,which is used as target water to produce [18f] fluoride for 18f [fdg] (18f fluorodeoxyglucose) synthesis,ozonolysis,ultrasonication,distillation methods separately and their combined forms were applied to samples. the removing of acetone,acetonitrile and ethanol using a combination of ozonization+ultrasonication method,the more suitable method for purification of [18o]h2o,was found higher than that of ozonization and ultrasonication methods alone. while the yield of 18f [fdg] from fresh [18o]h2o was 72%,the yield of 18f [fdg] from purified [18o]h2o was 69%. the results showed that the decrease in 18f [fdg] yield may be attributed to irradiation step only and obtained yield from purified irradiated [18o]h2o using combined purification method was sufficient for clinical purpose.