Monitoring of the antiviral potential of bee venom and wax extracts against Adeno-7 (DNA) and Rift Valley fever virus (RNA) viruses models

This study monitored the antiviral potential of bee venom and four wax extracts,ethanol white and black beeswax (eww/ebw) and acetone white and black beeswax (aww/abw) extracts. two different virus models namely adeno-7 as dna model and rvfv as rna virus models. end point calculation assay was used to calculate virus depletion titer. the depletion of viral infectivity titer of abw to adeno-7 virus showed strong antiviral activity recorded a depletion of viral infectivity titer (1.66 log (10)/ ml) that gave equal action with bee venom and more than interferon ifn (1 log (10)/ ml). on the other hand,antiviral activity of ebw showed a moderate potential,while aww showed no antiviral activity. finally eww showed synergetic activity against adeno-7 virus activity. thus,activity of wax extracts to rvfv was arranged in order of ifn bee venom > aww & ebw > eww and abw recorded 3.34,0.65,0.5,0.34 respectively. it is the first time to study the beeswax effect against dna and rna virus' models; acetone black beeswax recorded a depletion titer 1.66 log (10)/ml.