THE EFFICACY OF THREE MEDICINAL PLANTS: GARLIC,GINGER AND MIRAZID AND A CHEMICAL DRUG METRONIDAZOLE AGAINST CRYPTOSPORIDIUM PARVUM. I-IMMUNOLOGICAL RESPONSE

Cryptosporidisis parvum is a zoonotic protozoan parasite infects intestinal epithelial cells causing a major health problem for man and animals. experimentally the immunologic mediated elimination of c. parvum requires cd4+ t cells and ifn-gamma. but,the innate immune responses also have a significant protective role in both man and animals. the mucosal immune response to c. parvum in c57bl/6 neonatal and gko mice shows a concomitant thl and th2 cytokine mrna expression,with a crucial role for ifn-gamma in the resolution of the infection. nk cells and ifn-gamma have been shown to be important components in immunity in t and b cell-deficient mice,but ifn-gamma-dependent resistance is demonstrated in alymphocytic mice. epithelial cells may play a vital role in immunity as once infected these cells have increased expression of inflammatory chemokines and cytokines and demonstrate anti-infection killing mechanisms. c. parvum immunological response was used to evaluate the efficacy of anti-cryptosporidisis agents of garlic,ginger,mirazid and metronidazole in experimentally infected mice.