Thiazolidine esters: New potent urease inhibitors

A variety of esters of thiazolidine-4-caboxylic acid were synthesized and investigated for their urease inhibitory properties. a significant increase in urease inhibitory activities of these ester derivatives has been observed. the order of activity increases from methyl ester to heptyl ester but further prolongation of the alkyl chain was proved to be detrimental for receptor binding. these findings provide evidence that the nature of the alkyl chain has a significant impact on the coordination of thiazolidine esters with bi-metallic nickel center of urease. it was also observed that inhibition potentiated by lower ph and with increase in time.