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Antileishmanial activities of benzothiazole derivatives
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نویسنده
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rahim f. ,samreen h. e. j. research institute of chemistry ,taha m. ,saad s.m. ,perveen s. ,khan m. ,alam m.t. ,khan k.m. ,choudhary m.i.
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منبع
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journal of the chemical society of pakistan - 2015 - دوره : 37 - شماره : 1 - صفحه:157 -161
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چکیده
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Benzothiazole derivatives 1-22 were synthesized from 2-aminothiophenol and all synthetic compounds were screened for in vitro antileishmanial activity. these compound showed different types activities against leishmania with ic50 values ranging between 18.32 - 81.89 μm. compound 2 (ic50 = 18.32 ± 0.18 μm),5 (ic50 = 19.72 ± 0.32 μm),and 3 (ic50 = 21.87 ± 0.43 μm) were found to be the most active compounds among the series when compared to the standard (pentamidine,ic50 = 5.09 ± 0.04 μm). compounds 7 and 11 exhibited weak activities,while compounds 5,6,7,10,11,and 16 were also found active. however,remaining compounds were found to be inactive against leishmania. © 2015,chemical society of pakistan. all rights reserved.
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کلیدواژه
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Antileishmanial activity; Benzothiazole; Pentamidine
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آدرس
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h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi,karachi,pakistan,department of chemistry hazara university, Pakistan, international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, pcsir laboratories complex,karachi,shahrah-e-dr. salimuzzaman siddiqui, Pakistan, department of chemistry, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan, h. e. j. research institute of chemistry,international center for chemical and biological sciences,university of karachi, Pakistan
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Authors
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