Synthesis and biological studies of some new N-substituted derivatives of N-(1,3-Benzodioxol-5-yl)-4-methylbenzenesulfonamide

Sulfonamides are biologically active compounds with broad spectrum of activities. in the presented research,a small collection of n-alkyl/aralkyl substituted sulfonamides have been synthesized and investigated for inhibition of different bacterial strains. the 1,3-benzodioxol-5-amine (1) was treated with tosyl chloride (2) in water under mild basic conditions to yield the molecule,n-(1,3-benzodioxol-5-yl)-4-methylbenzenesulfonamide (3). the target compounds,5a-i,were obtained by stirring 3 with different electrophiles,4a-i,in the presence of n,n-dimethylformamide and sodium hydride. the structures of the synthesized compounds were established by spectroscopic techniques like ir,1h-nmr and ei-ms. these compounds were assayed for their antimicrobial activities via screening against gram-positive and gram-negative bacteria. the most of the compounds showed moderate activity against p. aeruginosa relative to reference standard drug,ciprofloxacin. © 2015,chemical society of pakistan. all rights reserved.